ABSTRACT
Myrtus, commonly called myrtle, is a genus of flowering plants in the Myrtaceae family. This study aimed to review myrtle's pharmaceutical, food, and other uses. The pharmacological effects of myrtle for antioxidant, antibacterial, and anti-inflammatory activities, reduction of COVID-19 symptoms, anti-diabetic in the animal model, hepatoprotective in the rat model, antihypertensive, control of intestinal helminthiasis in mice model, inhibition of glucosyltransferase activity, protective effect on oxidative metabolism in the hypothyroidism model, and reducing the damage caused by skin burns are reviewed. In addition, the food uses of this plant such as improving the oxidative and microbial stability of products containing salmon, antimicrobial activity in meat and dairy products, flavoring in sea salt, microbial improvement of fresh fruits during post-harvest storage, animal nutrition, and bio-oil production are summarized. © 2023, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
ABSTRACT
This paper examines the biological approach used to synthesize gold nanoparticles (AuNPs) by using Myrtus communis leaves extract as reducing agent and Chloroauric acid as precursors. Scanning Electron Microscopy (SEM), X-Ray Diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR) used in addition to UV-visible spectroscopy (UV) in order to characterize the AuNPs. The biosynthesized AuNPs exhibited inhibitory effects on ferritin and lactate dehydrogenase activity in sera of covid-19 patients and the sera of healthy control subjects;the inhibition percentage with LDH was 76.86% and 63% for patient and control group, respectively. While for ferritin activity, it was 85.85% for patient group and 75.18% for control group. Kinetic studies of ferritin and lactate dehydrogenase performed. Further studies on other biological activities were required to exploit AuNPs full potential. The goal of this study is to synthesized gold nanoparticles using simple, cheap and environmentally green method. This stage is more suited to large-scale manufacturing since it is speedy and removes the complex steps in other bio based methods (by using fungi and bacteria).
ABSTRACT
BACKGROUND: Since December 2019, the outbreak of coronavirus pneumonia was observed in China and quickly propagate in all of the world. Nowadays, many trials are underway on this disease in which the efficacy of various therapeutic remedies including chemical or natural agents as well as different non-pharmacological methods such as acupuncture are evaluated. This study aims at investigating the effect of M. communis fruit for treatment of COVID-19 disease. METHODS: We are performing an open-label randomized controlled trial on outpatients clinically suspected to COVID-19 disease in the age range of 18-65 years old with mild to moderate symptoms and without respiratory distress. Patients in both groups (M. communis and control) receive conventional therapy, but those in M. communis group get M. communis preparation in addition to conventional therapy. Intervention will continue for 5 days and the study outcomes including clinical status as well as mortality rate and adverse effects will be measured up to 14 days. DISCUSSION: The protocol describes the design of an ongoing randomized controlled trial to establish the evidence for the usage of water extract of M. communis fruit in clinically suspected COVID-19 disease and identify any safety concerns. TRIAL REGISTRATION: The trial has been registered at the Iranian Registry of Clinical Trials website under the code IRCT20180923041093N3 on March 28th, 2020 ( https://www.irct.ir/trial/46721 ). The results will be disseminated through manuscript publications and presentations to scientific meetings.